On Friday, September 22, 2023, the Journal of Inflammation Research published a study online that showed a correlation between a heightened systemic immune-inflammation index (SII) and the increased likelihood of all-cause and cardiovascular-specific mortality in patients on peritoneal dialysis.
In order to investigate the connection between the SII and mortality due to all causes and cardiovascular problems in those undergoing peritoneal dialysis, Li from the First Affiliated Hospital at Sun Yat-sen University in Guangzhou, China, and a team of colleagues collected data on 1,419 patients receiving peritoneal dialysis from 2007 to 2019 with a median follow-up period of 42 months.
It was discovered that a one-standard deviation rise in the SII was linked to greater all-cause mortality (hazard ratio, 1.202) and cardiovascular-specific mortality (hazard ratio, 1.280) after adjustment. In comparison to those with low SII, those with high SII had significantly greater risks for all-cause mortality (hazard ratio, 1.391) and cardiovascular-specific mortality (hazard ratio, 1.637). Subgroup analyses of persons under 65 years old had corresponding results.
The outcomes of the study demonstrated that a higher SII level was connected to a greater probability of all-cause and cardiovascular related deaths in individuals on peritoneal dialysis, particularly those aged 65 or younger. The authors state that further research is needed to assess the use of SII in clinical practice to predict mortality for patients on peritoneal dialysis.
A link to a peer-reviewed full text article (found here) showed that the Systemic Immune Inflammation Index was significantly associated.
Source: HealthDay